This book will serve as the preeminent text book on the topic of 'base excision repair', a key DNA repair pathway that protects cells from most spontaneous forms of DNA damage, including oxidative lesions that arise both in the nuclear and mitochondrial genomes. The book, which includes contributions from many of the world leaders in the field, provides a detailed description of the molecular mechanisms of base excision repair, as well as its emerging relationship to epigenetic regulation, the aging process and human disease, such as cancer susceptibility, immunological defects and neurological disorders. The book will also cover the state-of-the-art technologies being developed to assess base excision repair capacity among individuals in the population, in addition to the strategies being employed to target base excision repair as part of therapeutic paradigms to eradicate disease, namely cancer.This book represents one of the most extensive efforts to date to cover the topic of 'base excision repair'. It includes chapters by many of the most established investigators in the field, from all over the world.
History of Base Excision Repair (BER) and Book Overview (David M Wilson III); Uracil DNA Glycosylases (Hans Krokan); The GO System: OGG1 and MYH (Sheila David); NEIL and NTH1 Glycosylases (Susan Wallace); Alkylative DNA Glycosylase, AAG/MPG (Leona Samson); Abasic Endonuclease, APE1 (Gianluca Tell); DNA Polymerases in BER and Pathway Choice (Samuel Wilson); End-Processing in BER (Michael Weinfeld); PARP/XRCC1 Axis in BER (Janet Hall); DNA Ligases in BER (Alan Tomkinson); Post-Translational Regulation of BER (Robert Sobol); BER in Epigenetic Programming (TDG) (Primo Schar); BER in the Immune Response (SHM, CSR) (Carol Schrader); BER in Disease Etiology (Cancer, Lupus) (Joann Sweasy); BER in TNR Expansion Disorders (Margherita Bignami); BER in Neurological Disease (Yasaku Nakabeppu); Assessing BER Capacity in the Human Population (Zachary Nagel); BER as a Prognostic Marker (Srinivasan Madhusudan); BER as a Therapeutic Target (R Stephen Lloyd); Mitochondrial BER (Nadja de Souza Pinto); BER in Aging (Tinna Stevnsner);