In recent years, the emergence of new strains of antimicrobials with extraordinarily broad resistance has demanded that research follow a new course. "Bacterial Resistance to Antimicrobials" presents the most recent research findings. Extensively updated, this second edition features a historical introduction and new chapters on biofilms and the mechanism of multidrug tolerance as well as strategies for the development of new antibiotics. Additional topics include the genetics and mechanisms of resistance, methods for detecting and monitoring resistance, public health and medical practice, resistance problems associated with selected pathogens, and approaches to overcoming resistance.
Microbial Drug Resistance: A Historical Perspective, W.C. Summers Ecology of Antibiotic Resistance Genes, A.A. Salyers, N. Shoemaker, and D. Schlesinger Global Response Systems that Confer Resistance, P.F. Miller and P.N. Rather Multidrug Efflux Pumps: Structure, Efflux, and Inhibition, O. Lomovskaya, H.I. Zgurskaya, K.A. Bostian, and Kim Lewis Mechanisms of Aminoglycoside Antibiotic Resistance, G.D. Wright Resistance to ss-Lactam Antibiotics Mediated by ss-Lactamases, J.Y. Cha, L.P. Kotra, and S. Mobashery Target Modification as a Mechanism of Antimicrobial Resistance, D.C. Hooper Antibiotic Permeability, H. Taber Genetic Methods for Detecting Bacterial Resistance Genes, A.C. Fluit The Evolution and Epidemiology of Antibiotic Resistant Pneumococci, C.G. Dowson and K. Trzcinski Antimicrobial Resistance in the Enterococcus, G.M. Eliopoulos Methicillin Resistance in Staphylococcus aureus, K.S. Gilmore and M.S. Gilmore Mechanism of Drug Resistance in Mycobacterium tuberculosis, A.S. Pym and S.T. Cole Antibiotic Resistance in Enterobacteria, N.H Georgopapadakou Resistance as a Worldwide Problem, P. Shears Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings, C.R Friedman and A. Srinivasan Antibacterial Drug Discovery in the 21st Century, S.J. Projan