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Chronic Obstructive Pulmonary Disease
Pathogenesis to Treatment
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Main description:

Chronic obstructive pulmonary disease (COPD) is the most common respiratory disorder of adults in the developed world and is the fourth main cause of death in the USA. It is also associated with high morbidity, and poses an enormous burden of suffering and expense. Despite this, the disease has received little attention compared with other respiratory conditions such as asthma and lung cancer.



Current treatment can offer some marginal symptomatic relief but does not address the underlying disease process. Indeed, smoking cessation is the only intervention known to alter the rate of disease progression. There is clearly great need, and potential, for the development of superior therapies for symptomatic relief and disease modification. This book brings together leading researchers and physicians to discuss the most recent advances in our understanding of COPD, and draws together basic and clinical aspects relevant to the topic. Coverage includes the basic pathology, current and potential therapies, and detailed consideration of the major theories for the pathogenesis of COPD.


Back cover:

Chronic obstructive pulmonary disease (COPD) is the most common respiratory disorder of adults in the developed world and is the fourth main cause of death in the USA. It is also associated with high morbidity, and poses an enormous burden of suffering and expense. Despite this, the disease has received little attention compared with other respiratory conditions such as asthma and lung cancer.



Current treatment can offer some marginal symptomatic relief but does not address the underlying disease process. Indeed, smoking cessation is the only intervention known to alter the rate of disease progression. There is clearly great need, and potential, for the development of superior therapies for symptomatic relief and disease modification. This book brings together leading researchers and physicians to discuss the most recent advances in our understanding of COPD, and draws together basic and clinical aspects relevant to the topic. Coverage includes the basic pathology, current and potential therapies, and detailed consideration of the major theories for the pathogenesis of COPD.


Contents:

Overview of the pathology/pathogenesis

Overview of current therapies

Genetics

Mucus hypersecretion in COPD

Mechanisms of exacerbation

Epithelial and mesenchymal cells

Macrophage control of inflammation: negative pathways of regulation of inflammatory cytokines

Neutrophils

Lymphocytes

Oxidants/antioxidants

Proteases and anti–proteases –

I

Proteases and anti–proteases –

II

Alveolus formation: critical period, plasticity and retinoid regulation

Systemic effects of COPD

Potential novel therapies for COPD


PRODUCT DETAILS

ISBN-13: 9780470868676
Publisher: John Wiley & Sons Ltd (Wiley–Blackwell)
Publication date: October, 2008
Pages: 296
Dimensions: 157.00 x 235.00 x 18.00
Weight: 590g
Availability: Not available (reason unspecified)
Subcategories: Diseases and Disorders, General Practice

MEET THE AUTHOR

Science teachers (middle school to college); school–based leaders; teacher staff developers; college–level teacher educators in science instruction and their students.

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"The panel of speakers included some of the most distinguished scientists and physicians working in the field of COPD."
(Biochemie, No. 83, 2001)