Main description:

This book introduces the exciting field of orthobiology, which will usher in a new array of therapeutic approaches that stimulate the body's natural resources to regenerate musculoskeletal tissues damaged by trauma or disease. The book addresses a range of key topics and discusses emerging approaches that promise to offer effective alternatives to traditional treatments for injuries to bone, cartilage, muscles, ligaments, and tendons. It explains in detail how a variety of innovative products, including biomaterials, growth factors, and autogenous cells, together provide the basis for the regeneration of these musculoskeletal structures and how recent scientific progress has created unique opportunities to address pathological situations that until recently have been treated with unsatisfactory results. The authors are experts from across the world who come together to provide a truly global overview. The book is published in collaboration with ISAKOS. It will be invaluable for all with an interest in this area of medicine, which has already attained huge popularity in Orthopaedics and Sports Medicine and has also attracted the attention of the lay public.

Contents:

Bio orthopaedics: where are we now?- Optimization of Natural Healing.- Amniotic-derived biologics for connective tissue healing: Our best chance at tissue regeneration?- Physiology of the musculo-skeletal system, homeostasis, injury response and healing process.- Blood Products.- Biomaterials; Synthetic Tissue Augmentation.- Cell Culture.- Host environment; Scaffolds and Signaling (Tissue Engineering).- Stem Cells synovial derived.- Current state for clinical use of stem cells and platelet rich plasma.- Genes.- Orthopedic sports disorders : genetic and molecular aspects.- The Overview Orthobiology and Biomechanics.- The Challenge and the Promise of Bone Marrow Cells for Human Cartilage Repair.- Clinical Orthobiologic Approach to Acute Cartilage Injury.- Muscle anatomy, injury mechanism, natural healing and possible disability.- Emerging Orthobiologic Approaches to Muscle Injuries.- Clinical Orthobiologic Approach to Muscle Injuries.- Tendon anatomy, injury mechanism, acute versus chronic tendinopathies, natural healing and possible rupture.- Emerging Orthobiologic Approaches to Tendon Injuries.- Ligament anatomy, injury mechanism, different possibilities of healing according to anatomic location.- Relationship Between Biomechanics and Healing of Ligament Injuries: Natural evolution of untreated ligament injuries.- Emerging Orthobiologic Approaches to Ligament Injuries.- Clinical Orthobiologic Approach to Ligament Injury.- Bone anatomy and the biologic healing process of a fracture.- Emerging Orthobiologic Approaches to Fractures.- Clinical Orthobiologic Approach to Failure or Delay in Bone Healing.- Biological approach to avascular necrosis.- Natural history of meniscal injury.- Orthobiologics and meniscus healing.- Meniscus restoration.- Meniscal scaffolds evolution in the last 20 years.- Anatomy and physiology. Classification of cartilage lesions: acute versus chronic.- O.C.D. classification and natural story.- Emerging Orthobiologic Approaches to Cartilage Injury.- New approach to early O.A. of the patello femoral joint.- Clinical Orthobiologic Approach to Acute Cartilage Injury.- Future prospective.- Collagen membrane in repair cartilage defects.- The development of meniscal scaffolds.- Orthobiologics and regulations in different part of the world.- Scaffold-free stem cell-based tissue engineering to repair musculoskeletal tissues.- Orthokine treatment and/or treatment with ADSC for O-A of the knee.- Cell-free scaffolds for the treatment of chondral and osteochondral lesions.- Scaffolds for meniscus regeneration.- Joint congruence restoration in big osteochondral defects - the use of mesenchymal stem cells with the "sandwich" technique.- Biological reconstruction in patients with osteochondral defects: Postoperative management and MRI monitoring..- The role of biologic treatments for spine disorders.- How to teach new orthobiologic treatments.- Use of Adipose Derived Stem Cells in Sports Medicine.- Molecular aspects of using stem cells treatment.- The use of animal models and robotics to validate new bio therapies.- Meniscus Scaffolds: Past, Present and Future.