Main description:

This book addresses the current understanding of the diagnosis and management of biliary disease across all ages, with emphasis on how the latest advances in clinical science may be integrated into current and future therapies. The coverage is wide ranging, encompassing congenital and acquired conditions including cholestatic syndromes, biliary atresia, drug-induced cholestasis, primary biliary cholangitis/cirrhosis, primary sclerosing cholangitis, cholangiocarcinoma, gallstone disease, and autoimmune sclerosing cholangitis. With contributions from basic and clinical scientists, the relevance of state-of-the-art mechanistic biology to diagnosis, treatment, and future opportunities for drug design is clearly explained. The balance between science and clinical practice will ensure that this book makes a lasting contribution to the field. A broad readership will find the book easy to access and a rich source of information on current best practice and evolving management strategies.

Contents:

The clinical burden of biliary disease- a global perspective.- The healthy biliary tree- cellular and immunobiology.- Bile acid signalling and the current understanding of cholestasis: new opportunities for treatments?.- Animal models of biliary disease- current approaches and limitations.- The microbiome and human disease- a new organ of interest in biliary disease?.- Progressive familial intrahepatic cholestatic syndromes- genetic insights into biliary transporter function.- Biliary atresia- from pathology to treatment.- Drug induced cholestasis: mechanisms and importance.- Primary biliary cirrhosis- it's science and practice.- Primary sclerosing cholangitis- current concepts in biology and strategies for new therapy.- Cholangiocarcinoma- evaluation of risk and new treatment paradigms.- Gallstone disease in the 21st century: practice and controversies.- Autoimmune sclerosing cholangitis/IgG4 cholangiopathy- new diseases?.- Conclusions and future opportunities.