BOOKS BY CATEGORY
Your Account
Biased Signaling in Physiology, Pharmacology and Therapeutics
This book is currently unavailable – please contact us for further information.
Price
Quantity
€115.90
(To see other currencies, click on price)
Paperback / softback
Add to basket  

MORE ABOUT THIS BOOK

Main description:

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential.

Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.


Contents:

1. Introduction - Biased Signaling in Nature 2. The Role of Cell Background in Receptor Signaling 3. The Application of Signaling Bias to New Therapeutic Drug Therapy for 7 Transmembrane (G Protein-Coupled) Receptors: Quantifying Bias 4. Nuclear Hormone Receptors 5. Growth Factor Receptors 6. Ion Channels 7. Protein Conformational Dynamics in Pathophysiology 8. Biased Signaling in Therapeutics


PRODUCT DETAILS

ISBN-13: 9780128103104
Publisher: Elsevier (Academic Press Inc)
Publication date: October, 2018
Pages: 316
Weight: 652g
Availability: Not available (reason unspecified)
Subcategories: Anatomy, Counselling & Therapy, Pharmacology, Physiology

CUSTOMER REVIEWS

Average Rating