Main description:

The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.

Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.

Contents:

1. Mechanism of Controlling Blood Vessel Growth and Development and Identification of Therapeutics Against Pathological Angiogenesis
2. Development of In Vitro Method for Assaying Anti-Angiogenic Effect of Drugs
3. Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis: Which Actors to Target for Treatment?
4. Inhibition of Angiogenesis in Cancer Management by Antioxidants: Ascorbate and P. leucotomos
5. Development of Novel Anti-Cancer Strategies Based on Angiogenesis Inhibition
6. Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer
7. STAT3 Signaling in Cancer: Small Molecule Intervention as Therapy?
8. Anti-Angiogenic Therapy and Cardiovascular Diseases: Current Strategies and Future Perspectives