Main description:

A rise in the number of young and old patients suffering from a stroke or traumatic brain injury has led to the need for better drug development and treatment, as well as diagnosis and prevention of ischemic stroke and traumatic brain injury. This book provides a comprehensive overview of scientific advancements in these areas.

Chapters provide the latest knowledge in neuroscience, biotechnology, and personalized medicine applicable to acute brain injuries. Development of neuroprotective drugs is treated in detail. Chemical biomarkers for detection, imaging and preventative strategies are covered to provide medicinal chemists with a broad view of translational aspects of the field.

This book will be useful to postgraduate students and researchers in medicinal chemistry and pharmacology as well as specialists in the acute brain injury field.

Contents:

Transient Ischemic Attack, Traumatic Brain Injury, and Ischemic Stroke: Risk Factors and Treatments; Inflammatory Changes in Cerebral Ischemic Injury: Cellular and Molecular Involvement; Biomarkers of Acute Brain Injury and Surrogate Endpoints in Traumatic Brain Injury and Stroke Translational Studies; Difficulties of Translating Outcomes from Animal Studies to Clinical Trials; Neuroprotective Therapies for Ischemic Stroke; The Molecular Neuroprotective Strategies in Cerebral Ischemia: An Insight into Emerging Treatments for Oxidative Stress; Identification of MicroRNAs as Targets for Treatment of Ischemic Stroke; Combined Drug-Diagnostic Test Co-development for Predicting and Preventing Brain Impairments; Advances in Diagnostics and Treatment of Neurotoxicity after Sports-related Injuries; Functional Predictors for Prognosis and Recovery after Mild Traumatic Brain Injury; Predictors for Prognosis and Recovery from Unconsciousness Due to Brain Trauma; Neurotoxicity in Spinal Cord Impairments; Advanced Approaches in Stem Cell Therapy for Stroke and Traumatic Brain Injury; Testing and Mechanisms of Neuroprotective Agents for Cerebral Ischemic Injury in Clinical Trials, 2010-2016; Difficulties in Clinical Trials to Treat Traumatic Brain Injury and Stroke; Challenges in Using Biomarkers in Central Nervous System Applications; Resolving Difficult Case Scenarios by Incorporating Stroke Biomarkers in Clinical Decision-making; Development of Novel Test Platforms for the Assessment of Brain Injury; Advancements and Challenges in Hyperacute Stroke Translational Research